Heart Disease

2022 | Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock

150 150 sabrina.agostini@uhn.ca

Short Description: Cardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in haematopoietic stem cells lead to clonal expansion and the development of inflammation. This study aims to assess the prevalence of CH and its association with survival in a population of CS patients in a quaternary centre.
Interest: Cardiogenic Shock, Heart Disease, Heart Failure, Genomics, Molecular Biology
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2021 | Recurrent Myocarditis Induced by Immune-Checkpoint Inhibitor Treatment Is Accompanied by Persistent Inflammatory Markers Despite Immunosuppressive Treatment

150 150 admpmccbiobank

Short Description: A case report of recurrent myocarditis in a patient previously treated with a programmed death ligand I inhibitor, an immune checkpoint inhibitor that blocks the binding of PD-L1 to programmed cell death protein 1 and CD80.
Interest: Cancer, Cardio-Oncology, Cardiology, Heart disease, Myocarditis
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