Genomics

2022 | Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock

 150 150 sabrina.agostini@uhn.ca
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Short Description: Cardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in haematopoietic stem cells lead to clonal expansion and the development of inflammation. This study aims to assess the prevalence of CH and its association with survival in a population of CS patients in a quaternary centre.
Interest: Cardiogenic Shock, Heart Disease, Heart Failure, Genomics, Molecular Biology
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2022 | Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients

 150 150 sabrina.agostini@uhn.ca
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FIGURE. Survival analysis in orthotopic heart transplantation recipients according to the presence of clonal hematopoiesis gene mutations. CH, clonal hematopoiesis

Short Description: Novel risk stratification and non-invasive surveillance methods are needed in orthotopic heart transplant (OHT) to reduce morbidity and mortality post-transplant. Clonal hematopoiesis (CH) refers to the acquisition of specific gene mutations in hematopoietic stem cells linked to enhanced inflammation and worse cardiovascular outcomes. The purpose of this study was to investigate the association between CH and OHT. Blood samples were collected from 127 OHT recipients. Error-corrected sequencing was used to detect CH-associated mutations. We evaluated the association between CH and acute cellular rejection, CMV infection, cardiac allograft vasculopathy (CAV), malignancies, and survival.
Interest: Genomics, Heart Transplantation, Cardiology, Molecular Biology
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